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Livres
Articles (40)
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Total Synthesis of (+)-Carbonolide B

Keck, Gary E., Palani, Anandan, McHardy, Stanton F.

Journal:

Journal of Organic Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.47 MB

english, 1994

Total Synthesis of (+)-7-Deoxypancratistatin: A Radical Cyclization Approach

Keck, Gary E., McHardy, Stanton F., Murry, Jerry A.

Journal:

Journal of the American Chemical Society

Année:

1995

Langue:

english

Fichier:

PDF, 238 KB

english, 1995

ChemInform Abstract: Shock Sensitivity of a Vinamidinium Bis-perchlorate Reagent and Demonstration of a Lower Energy Alternative.

John A. Ragan, Ruth E. McDermott, Brian P. Jones, David J. am Ende, Pamela J. Clifford, Stanton J. McHardy, Steven D. Heck, Spiros Liras, Barb E. Segelstein

Journal:

ChemInform

Année:

2000

Fichier:

PDF, 29 KB

2000

Diastereoselective 6- e xo Radical Cyclizations of Oxime Ethers: Total Synthesis of 7-Deoxypancratistatin

Keck, Gary E., McHardy, Stanton F., Murry, Jerry A.

Journal:

Journal of Organic Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 371 KB

english, 1999

Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015)

McHardy, Stanton F., Wang, Hua-Yu Leo, McCowen, Shelby V., Valdez, Matthew C.

Journal:

Expert Opinion on Therapeutic Patents

Année:

2017

Langue:

english

Fichier:

PDF, 1.53 MB

english, 2017

Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?

Rugel, Anastasia R., Guzman, Meghan A., Taylor, Alexander B., Chevalier, FrÃ©dÃ©ric D., Tarpley, Reid S., McHardy, Stanton F., Cao, Xiaohang, Holloway, Stephen P., Anderson, Timothy J.C., Hart, P. Joh

Journal:

International Journal for Parasitology Drugs and Drug Resistance

Année:

2020

Fichier:

PDF, 1.78 MB

2020

ChemInform Abstract: A Second-Generation Radical-Based Synthesis of (+)-7-Deoxypancratistatin.

Gary E. Keck, Travis T. Wager, Stanton F. McHardy

Journal:

ChemInform

Année:

1999

Fichier:

PDF, 33 KB

1999

ChemInform Abstract: Diastereoselective 6-exo Radical Cyclizations of Oxime Ethers: Total Synthesis of 7-Deoxypancratistatin.

Gary E. Keck, Stanton F. McHardy, Jerry A. Murry

Journal:

ChemInform

Année:

1999

Fichier:

PDF, 34 KB

1999

ChemInform Abstract: Reductive Cleavage of N—O Bonds in Hydroxylamines and Hydroxamic Acid Derivatives Using Samarium Diiodide.

Gary E. Keck, Travis T. Wager, Stanton F. McHardy

Journal:

ChemInform

Année:

2000

Langue:

english

Fichier:

PDF, 36 KB

english, 2000

Reductive cleavage of NO bonds in hydroxylamine and hydroxamic acid derivatives using SmI2/THF

Gary E. Keck, Stanton F. McHardy, Travis T. Wager

Journal:

Tetrahedron Letters

Année:

1995

Langue:

english

Fichier:

PDF, 227 KB

english, 1995

Biaryl piperidines as potent and selective delta opioid receptor ligands

Spiros Liras, Stanton F. McHardy, Martin P. Allen, Barb E. Segelstein, Steven D. Heck, Dianne K. Bryce, Anne W. Schmidt, Michelle Vanase-Frawley, Ernesto Callegari, Stafford McLean

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2010

Reductive cleavage of NO bonds in hydroxylamines and hydroxamic acid derivatives using samarium diiodide

Gary E. Keck, Travis T. Wager, Stanton F. McHardy

Journal:

Tetrahedron

Année:

1999

Langue:

english

Fichier:

PDF, 887 KB

english, 1999

Some unusual reactions of weinreb amides

Gary E. Keck, Stanton F. McHardy, Jerry A. Murry

Journal:

Tetrahedron Letters

Année:

1993

Langue:

english

Fichier:

PDF, 273 KB

english, 1993

18F-FDG microPET imaging detects early transient response to an IGF1R inhibitor in genetically engineered rhabdomyosarcoma models

Anuradha Soundararajan, Jinu Abraham, Laura D. Nelon, Suresh I. Prajapati, Lee Ann Zarzabal, Joel E. Michalek, Stanton F. McHardy, Douglas S. Hawkins, Suman Malempati, Charles Keller

Journal:

Pediatric Blood & Cancer

Année:

2012

Langue:

english

Fichier:

PDF, 433 KB

english, 2012

Design and Discovery of a Selective Small Molecule κ Opioid Antagonist (2-Methyl- N -((2′-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242)

Verhoest, Patrick R., Sawant Basak, Aarti, Parikh, Vinod, Hayward, Matthew, Kauffman, Gregory W., Paradis, Vanessa, McHardy, Stanton F., McLean, Stafford, Grimwood, Sarah, Schmidt, Anne W., Vanase-Fra

Journal:

Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.82 MB

english, 2011

Discovery of CP-866,087, a mu opioid receptor antagonist for the treatment of alcohol abuse and dependence

McHardy, Stanton F., Heck, Steven D., Guediche, Sara, Kalman, Monica, Allen, Martin P., Tu, Meihua, Bryce, Dianne K., Schmidt, Anne W., Vanase-Frawley, Michelle, Callegari, Ernesto, Doran, Shawn, Grah

Journal:

MedChemComm

Année:

2011

Langue:

english

Fichier:

PDF, 151 KB

english, 2011

Discovery and pharmacological characterization of a selective delta opiate receptor antagonist (CP-646,777)

Liras, Spiros, McHardy, Stanton F., Allen, Martin P., Segelstein, Barb E., Heck, Steven D., Bryce, Dianne K., Schmidt, Anne W., O'Connor, Rebecca, Vanase-Frawley, Michelle, Callegari, Ernesto, McLean,

Journal:

MedChemComm

Année:

2011

Langue:

english

Fichier:

PDF, 169 KB

english, 2011

Design, synthesis, and characterization of novel, nonquaternary reactivators of GF-inhibited human acetylcholinesterase

McHardy, Stanton F., Bohmann, Jonathan A., Corbett, Michael R., Campos, Bismarck, Tidwell, Michael W., Thompson, Paul Marty, Bemben, Chris J., Menchaca, Tony A., Reeves, Tony E., Cantrell, William R.,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2014

Langue:

english

Fichier:

PDF, 621 KB

english, 2014

A Second-Generation Radical-Based Synthesis of (+)-7-Deoxypancratistatin †

Keck, Gary E., Wager, Travis T., McHardy, Stanton F.

Journal:

Journal of Organic Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 225 KB

english, 1998

Molecular docking analysis of mitochondrial pyruvate carrier (MPC) 1 and 2 with pyruvate and inhibitors: Thiazolidinediones currently in clinical trials to delay mild cognitive impairment and Alzheimer’s disease

Phelix, Clyde F., Perry, George, McHardy, Stanton F.

Journal:

Alzheimer's & Dementia

Année:

2015

Langue:

english

Fichier:

PDF, 1006 KB

english, 2015

Molecular dynamics study of human carbonic anhydrase II in complex with Zn2+ and acetazolamide on the basis of all-atom force field simulations

Wambo, Thierry O., Chen, Liao Y., McHardy, Stanton F., Tsin, Andrew T.

Journal:

Biophysical Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 1.73 MB

english, 2016

Targeting Candida albicans filamentation for antifungal drug development

Vila, Taissa, Romo, Jesus A., Pierce, Christopher G., McHardy, Stanton F., Saville, Stephen P., Lopez-Ribot, Jose L.

Journal:

Virulence

Année:

2016

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2016

1,3-propanediol binds deep inside the channel to inhibit water permeation through aquaporins

Yu, Lili, Rodriguez, Roberto A., Chen, L. Laurie, Chen, Liao Y., Perry, George, McHardy, Stanton F., Yeh, Chih-Ko

Journal:

Protein Science

Année:

2016

Langue:

english

Fichier:

PDF, 1.92 MB

english, 2016

A novel small molecule inhibitor of Candida albicans biofilm formation, filamentation and virulence with low potential for the development of resistance

Pierce, Christopher G, Chaturvedi, Ashok K, Lazzell, Anna L, Powell, Alexander T, Saville, Stephen P, McHardy, Stanton F, Lopez-Ribot, Jose L

Journal:

npj Biofilms and Microbiomes

Année:

2015

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2015

Noncoupled Fluorescent Assay for Direct Real-Time Monitoring of Nicotinamide N -Methyltransferase Activity

Neelakantan, Harshini, Vance, Virginia, Wang, Hua-Yu Leo, McHardy, Stanton F., Watowich, Stanley J.

Journal:

Biochemistry

Année:

2017

Langue:

english

Fichier:

PDF, 935 KB

english, 2017

Structure Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

Neelakantan, Harshini, Wang, Hua-Yu, Vance, Virginia, Hommel, Jonathan D, McHardy, Stanton F, Watowich, Stanley J.

Journal:

Journal of Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2017

Structural and Enzymatic Insights into Species-specific Resistance to Schistosome Parasite Drug Therapy

Taylor, Alexander B., Roberts, Kenneth M., Cao, Xiaohang, Clark, Nathaniel E., Holloway, Stephen P., Donati, Enrica, Polcaro, Chiara M., Pica-Mattoccia, Livia, Tarpley, Reid S., McHardy, Stanton F., C

Journal:

Journal of Biological Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 879 KB

english, 2017

Electrochemical Substrate and Assay for Esterolytic Activity of Human White Blood Cells

Hanson, Douglas, Menard, Travis, McHardy, Stanton F, Fleischman, Andrew, Gorski, Waldemar

Journal:

Analytical Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2017

Structure-activity relationships of new natural product-based diaryloxazoles with selective activity against androgen receptor-positive breast cancer cells

Robles, Andrew J., McCowen, Shelby, Cai, Shengxin, Glassman, Michaels, Ruiz, Francisco, Cichewicz, Robert H., McHardy, Stanton F, Mooberry, Susan L.

Journal:

Journal of Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 2.29 MB

english, 2017

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice

Neelakantan, Harshini, Vance, Virginia, Wetzel, Michael D., Leo Wang, Hua-Yu, McHardy, Stanton F., Finnerty, Celeste C., Hommel, Jonathan D., Watowich, Stanley J.

Journal:

Biochemical Pharmacology

Année:

2017

Langue:

english

Fichier:

PDF, 1.23 MB

english, 2017

Novel Small-Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice

Blasio, Angelo, Wang, Jingyi, Wang, Dan, Varodayan, Florence P., Pomrenze, Matthew B., Miller, Jacklyn, Lee, Anna M., McMahon, Thomas, Gyawali, Sandeep, Wang, Hua-Yu, Roberto, Marisa, McHardy, Stanton

Journal:

Biological Psychiatry

Année:

2017

Langue:

english

Fichier:

PDF, 1.05 MB

english, 2017

Development of Anti-Virulence Approaches for Candidiasis via a Novel Series of Small-Molecule Inhibitors of Candida albicans Filamentation

Romo, Jesus A., Pierce, Christopher G., Chaturvedi, Ashok K., Lazzell, Anna L., McHardy, Stanton F., Saville, Stephen P., Lopez-Ribot, Jose L., Heitman, Joseph

Journal:

mBio

Année:

2017

Langue:

english

Fichier:

PDF, 2.58 MB

english, 2017

Synthesis and Characterization of Pyridine Compounds for Amperometric Measurements of Leukocyte Esterase

Hanson, Douglas, Menard, Travis, Blazek, Teresa, McHardy, Stanton, Gorski, Waldemar

Journal:

ChemBioChem

Année:

2018

Langue:

english

Fichier:

PDF, 1.59 MB

english, 2018

Synthesis and SAR of Novel Capsazepine Analogs with Significant Anti-Cancer Effects in Multiple Cancer Types

Chapa, Jorge De La, Valdez, Matthew, Ruiz, Franscisco, Gonzales, Keith, Mitchell, Wes, McHardy, Stanton F., Hart, Matthew, Polusani, Srikanth R., Gonzales, Cara B.

Journal:

Bioorganic & Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2018

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

Neelakantan, Harshini, Brightwell, Camille R., Graber, Ted Gfoch., Maroto, Rosario, Wang, Hua-Yu Leo, McHardy, Stanton F., Papaconstantinou, John, Fry, Christopher S., Watowich, Stanley J.

Journal:

Biochemical Pharmacology

Année:

2019

Langue:

english

Fichier:

PDF, 1.86 MB

english, 2019

The Novel Capsazepine Analog, CIDD-99, Significantly Inhibits Oral Squamous Cell Carcinoma In Vivo Through a TRPV1-Independent Induction of ER Stress, Mitochondrial Dysfunction, and Apoptosis

De La Chapa, Jorge J., Singha, Prajjal K., Self, Kristen K., Sallaway, McKay L., McHardy, Stanton F., Hart, Matthew, McGuff, H. Stan, Valdez, Matthew C., Ruiz, Francisco, Polusani, Srikanth R., Gonzal

Journal:

Journal of Oral Pathology & Medicine

Année:

2019

Langue:

english

Fichier:

PDF, 462 KB

english, 2019

A modular PROTAC design for target destruction using a degradation signal based on a single amino acid

Shanmugasundaram, Karthigayan, Shao, Peng, Chen, Han, Campos, Bismarck, McHardy, Stanton F., Luo, Tuoping, Rao, Hai

Journal:

Journal of Biological Chemistry

Année:

2019

Langue:

english

Fichier:

PDF, 11.65 MB

english, 2019

A modular PROTAC design for target destruction using a degradation signal based on a single amino acid

Shanmugasundaram, Karthigayan, Shao, Peng, Chen, Han, Campos, Bismarck, McHardy, Stanton F., Luo, Tuoping, Rao, Hai

Journal:

Journal of Biological Chemistry

Année:

2019

Fichier:

PDF, 11.65 MB

2019

Infection Screening in Biofluids with Glucose Test Strips

Bekhit, Michael, Wang, Hua-Yu, McHardy, Stanton F, Gorski, Waldemar

Journal:

Analytical Chemistry

Année:

2020

Fichier:

PDF, 724 KB

2020

Diabetic strips as coulometric sensors for hydroquinone and leukocyte esterase

Bekhit, Michael, Wang, Hua-Yu, Menard, Travis, McHardy, Stanton, Gorski, Waldemar

Journal:

Journal of Electroanalytical Chemistry

Année:

2020

Fichier:

PDF, 701 KB

2020